New blood test finds elusive fetal gene problem

A NEW non-invasive blood test for pregnant women could make it easier to catch abnormalities before their child is born.

Human cells should have two copies of each chromosome but sometimes the division is uneven. Existing tests count the fragments of placental DNA in the mother's blood. If the fragments from one chromosome are unusually abundant, it might be because the fetus has an extra copy of that chromosome. But triploidy, where there are three copies of every chromosome, is missed, since the proportion of fragments from each chromosome is the same.

California-based company Natera uses an algorithm to calculate the most likely genotype for the fetus. To do this it looks at single letter variations called SNPs in the parents and compares this to a database of the most common SNPs patterns in the population. This genotype is then compared with placental DNA.

This approach can catch triploidy since the whole fetal genotype is the reference rather than a single chromosome. The method was presented last week at the Society for Maternal-Fetal Medicine in San Francisco.

This article appeared in print under the headline "No hiding place for fetal gene errors"

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Pope celebrates emotional last Sunday prayer

VATICAN CITY: Pope Benedict XVI delivered an emotional last Sunday prayer in St Peter's Square, saying God had told him to devote himself to prayer but assuring supporters he would not "abandon" the Church.

Tens of thousands of supporters turned out for the historic prayers ahead of the pope's formal resignation on Thursday, often interrupting the pope with their clapping, cheering and chanting.

"The Lord is calling me to climb the mountain, to dedicate myself even more to prayer and meditation. But this does not mean abandoning the Church," the pope told the crowd from the window of his residence in the Apostolic Palace in the Vatican.

"If God is asking me to do this, it is precisely so I can continue to serve with the same dedication and love as before but in a way that is more appropriate for my age and for my strength."

The 85-year-old leader of the world's 1.2 billion Catholics has said he will step down because he no longer has the strength of mind and body to carry on.

His shock resignation ended an eight-year pontificate dominated by the priest child sex abuse scandal and efforts to counter rising secularism in the West.

He thanked the crowd with a final unscripted call, telling them: "We will always be close!"

The Vatican and Rome police estimated the numbers at more than 100,000 people -- many times more than usually attend the traditional Sunday prayer.

"Holy Father, We Love You", read one banner seen in the crowd. One read: "Thank You, Your Holiness" and another said: "Dear Father, We'll Miss You".

"I have come to support the pope and to ask for his blessing," said Joao-Paulo, a 26-year-old trainee priest from Brazil who came with fellow seminarians.

Birgit Marschall, 37, a teacher from Germany, said: "He is an intellectual who speaks in simple language, who writes what we have in our hearts."

Claire Therese Heyne, a 34-year-old theology student from the United States, said the pope "must have had a very strong reason" to leave.

"It is an act of courage and humility," she said.

Benedict will be only the second pope to resign of his own free will in the Church's 2,000-year history, and the first to do so since the Middle Ages.

But Gianpaolo, 33, said Benedict had been "less courageous" than his predecessors, and many people looked ahead to the pope's successor and stressed the need for major reforms.

"The Church has to have a major reflection after this resignation. Something has changed inside the Church and this decision reflects this," said Gianpaolo, who came with his two sons.

Forty-five-year old Linda came from Wales in Britain for the event, saying: "He was not so open as the last popes before him. A new pope should be more open to people, to new ideas."

There was tight security in and around the Vatican, with more than 100 police officers and snipers on surrounding buildings, as well as two field clinics and hundreds of volunteers to help pilgrims.

The security is being seen as preparation for the pope's final general audience in St Peter's on Wednesday where around 200,000 people are expected.

Some Italian media have speculated his health may be far worse than the Vatican revealed, and others have said an explosive report into the "Vatileaks" scandal may be to blame.

The Vatican's Secretariat of State -- effectively the government of the Catholic Church -- took the unusual step on Saturday of issuing a formal statement condemning "completely false news stories".

The Panorama news weekly and the Repubblica daily said a report by a committee of cardinals into the leaks of confidential papal papers last year had uncovered allegations of intrigue, corruption and blackmail in the Vatican.

No clear favourite has emerged to succeed Joseph Ratzinger. But many observers say the cardinals, who make the choice, may plump for a much younger candidate who is a more pastoral figure than the academic Benedict.

A series of meetings of cardinals starting Friday will determine the date of the start of the conclave to elect a new pope. The Vatican has hinted that it could be brought forward to early March since there is no papal funeral.

Conclaves can last for days before a candidate wins a two-thirds majority.

The Vatican has said Benedict will retire to the papal summer residence of Castel Gandolfo near Rome for the next two or three months while a former monastery inside the Vatican is renovated.

Benedict has said he will live "hidden from the world" but Vatican spokesman Federico Lombardi has said he could provide "spiritual guidance" to his successor and will likely continue to publish his theological research.

- AFP/fa

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Mozilla, AT&T show WebRTC phone-Web communications link

BARCELONA, Spain--Mozilla, Ericsson, and AT&T announced today they're demonstrating technology to place Internet-based voice and video calls that bridge between traditional telephone services and the Web.

The demonstration, at Mobile World Congress here, uses the nascent WebRTC (Web Real-Time Communications) standard to set up browser-based communications between different devices.

The "proof of concept" links a Web app with a person's existing phone number and "shows how consumers can easily take and receive video calls from their mobile phones or desktop browser using WebRTC or share their web experiences with friends or family who might be on a desktop PC or mobile phone across the other side of the world," Mozilla said in a blog post. "The demonstration also shows how
Firefox can perform many functions usually confined to a mobile device, such as voice and video calls and SMS/MMS messaging."

The demo uses Ericsson network equipment called the Web Communication Gateway, Ericsson said in its announcement.

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Elderly Abandoned at World's Largest Religious Festival

Every 12 years, the northern Indian city of Allahabad plays host to a vast gathering of Hindu pilgrims called the Maha Kumbh Mela. This year, Allahabad is expected to host an estimated 80 million pilgrims between January and March. (See Kumbh Mela: Pictures From the Hindu Holy Festival)

People come to Allahabad to wash away their sins in the sacred River Ganges. For many it's the realization of their life's goal, and they emerge feeling joyful and rejuvenated. But there is also a darker side to the world's largest religious gathering, as some take advantage of the swirling crowds to abandon elderly relatives.

"They wait for this Maha Kumbh because many people are there so nobody will know," said one human rights activist who has helped people in this predicament and who wished to remain anonymous. "Old people have become useless, they don't want to look after them, so they leave them and go."

Anshu Malviya, an Allahabad-based social worker, confirmed that both men and women have been abandoned during the religious event, though it has happened more often to elderly widows. Numbers are hard to come by, since many people genuinely become separated from their groups in the crowd, and those who have been abandoned may not admit it. But Malviya estimates that dozens of people are deliberately abandoned during a Maha Kumbh Mela, at a very rough guess.

To a foreigner, it seems puzzling that these people are not capable of finding their own way home. Malviya smiles. "If you were Indian," he said, "you wouldn't be puzzled. Often they have never left their homes. They are not educated, they don't work. A lot of the time they don't even know which district their village is in."

Once the crowd disperses and the volunteer-run lost-and-found camps that provide temporary respite have packed away their tents, the abandoned elderly may have the option of entering a government-run shelter. Conditions are notoriously bad in these homes, however, and many prefer to remain on the streets, begging. Some gravitate to other holy cities such as Varanasi or Vrindavan where, if they're lucky, they are taken in by temples or charity-funded shelters.

In these cities, they join a much larger population, predominantly women, whose families no longer wish to support them, and who have been brought there because, in the Hindu religion, to die in these holy cities is to achieve moksha or Nirvana. Mohini Giri, a Delhi-based campaigner for women's rights and former chair of India's National Commission for Women, estimates that there are 10,000 such women in Varanasi and 16,000 in Vrindavan.

But even these women are just the tip of the iceberg, says economist Jean Drèze of the University of Allahabad, who has campaigned on social issues in India since 1979. "For one woman who has been explicitly parked in Vrindavan or Varanasi, there are a thousand or ten thousand who are living next door to their sons and are as good as abandoned, literally kept on a starvation diet," he said.

According to the Hindu ideal, a woman should be looked after until the end of her life by her male relatives—with responsibility for her shifting from her father to her husband to her son. But Martha Chen, a lecturer in public policy at Harvard University who published a study of widows in India in 2001, found that the reality was often very different.

Chen's survey of 562 widows of different ages revealed that about half of them were supporting themselves in households that did not include an adult male—either living alone, or with young children or other single women. Many of those who did live with their families reported harassment or even violence.

According to Drèze, the situation hasn't changed since Chen's study, despite the economic growth that has taken place in India, because widows remain vulnerable due to their lack of education and employment. In 2010, the World Bank reported that only 29 percent of the Indian workforce was female. Moreover, despite changes in the law designed to protect women's rights to property, in practice sons predominantly inherit from their parents—leaving women eternally dependent on men. In a country where 37 percent of the population still lives below the poverty line, elderly dependent relatives fall low on many people's lists of priorities.

This bleak picture is all too familiar to Devshran Singh, who oversees the Durga Kund old people's home in Varanasi. People don't pay toward the upkeep of their relatives, he said, and they rarely visit. In one case, a doctor brought an old woman to Durga Kund claiming she had been abandoned. After he had gone, the woman revealed that the doctor was her son. "In modern life," said Singh, "people don't have time for their elderly."

Drèze is currently campaigning for pensions for the elderly, including widows. Giri is working to make more women aware of their rights. And most experts agree that education, which is increasingly accessible to girls in India, will help improve women's plight. "Education is a big force of social change," said Drèze. "There's no doubt about that."

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Crash at Daytona Exposes Risks to Fans

The risks of racing extend beyond the drivers.

Fans can wind up in the danger zone, too.

A horrifying crash on the last lap of a race at Daytona International Speedway injured at least 30 fans Saturday and provided another stark reminder of what can happen when a car going nearly 200 mph is suddenly launched toward the spectator areas.

The victims were sprayed with large chunks of debris — including a tire — after rookie Kyle Larson's machine careened into the fencing that is designed to protect the massive grandstands lining NASCAR's most famous track.

"I love the sport," said Shannan Devine, who witnessed the carnage from her 19th-row seat, about 250 feet away. "But no one wants to get hurt over it."

The fencing served its primary purpose, catapulting what was left of Larson's car back onto the track. But it didn't keep potentially lethal shards from flying into the stands.

"There was absolute shock," Devine said. "People were saying, 'I can't believe it, I can't believe it. I've never seen this happen, I've never seen this happen. Did the car through the fence?' It was just shock and awe. Grown men were reaching out and grabbing someone, saying, 'Oh my gosh! Oh my gosh!' It was just disbelief, absolute disbelief."

From Daytona to Le Mans to a rural road in Ireland, auto racing spectators have long been too close to the action when parts start flying. The crash in the second-tier Nationwide race follows a long list of accidents that have left fans dead or injured.

The most tragic incident occurred during the 1955 24 Hours of Le Mans, when two cars collided near the main stands. The wreck sent debris hurtling into the crowd, while one of the cars flipped upside down and exploded in a giant fireball.

Eighty-three spectators and driver Pierre Levegh were killed, and 120 fans were injured.

The Daytona crash began as the field approached the checkered flag and leader Regan Smith attempted to block Brad Keselowski. That triggered a chain reaction, and rookie Kyle Larson hit the cars in front of him and went airborne into the fence.

The entire front end was sheared off Larson's car, and his burning engine wedged through a gaping hole in the fence. Chunks of debris from the car were thrown into the stands, including a tire that cleared the top of the fence and landed midway up the spectator section closest to the track.

"I thought the car went through the fence," Devine said. "I didn't know if there was a car on top of people. I didn't know what to think. I'm an emotional person. I immediately started to cry. It was very scary, absolutely scary. I love the speed of the sport. But it's so dangerous."

The fencing used to protect seating areas and prevent cars from hurtling out of tracks has long been part of the debate over how to improve safety.

Three-time Indianapolis 500 winner Dario Franchitti lost close friend Dan Wheldon at Las Vegas in the 2011 IndyCar season finale, when Wheldon's car catapulted into the fencing and his head struck a support post. Since his death, IndyCar drivers have called for studies on how to improve the safety barriers.

Franchitti renewed the pleas on Twitter after the Daytona crash, writing "it's time (at)Indycar (at)nascar other sanctioning bodies & promoters work on an alternative to catch fencing. There has to be a better solution."

Another fan who witnessed the crash said he's long worried that sizable gaps in the fencing increase the chances of debris getting through to the stands.

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Amazon to open market in second-hand MP3s and e-books

A new market for second-hand digital downloads could let us hold virtual yard sales of our ever-growing piles of intangible possessions

WHY buy second-hand? For physical goods, the appeal is in the price – you don't mind the creases in a book or rust spots on a car if it's a bargain. Although digital objects never lose their good-as-new lustre, their very nature means there is still uncertainty about whether we actually own them in the first place, making it tricky to set up a second-hand market. Now an Amazon patent for a system to support reselling digital purchases could change that.

Amazon's move comes after last year's European Union ruling that software vendors cannot stop customers from reselling their products. But without technical support, the ruling has had no impact. In Amazon's system, customers will keep their digital purchases – such as e-books or music – in a personal data store in the cloud that only they can access, allowing them to stream or download the content.

This part is like any cloud-based digital locker except that the customer can resell previous purchases by passing the access rights to another person. Once the transaction is complete, the seller will lose access to the content. Any system for reselling an e-book, for example, would have to ensure that it is not duplicated in the transaction. That means deleting any copies the seller may have lying around on hard drives, e-book readers, and other cloud services, since that would violate copyright.

Amazon may be the biggest company to consider a second-hand market, but it is not the first. ReDigi, based in Boston, has been running a resale market for digital goods since 2011. After downloading an app, users can buy a song on ReDigi for as little as 49 cents that would costs 99 cents new on iTunes.

When users want to sell an item, they upload it to ReDigi's servers via a mechanism that ensures no copy is made during the transfer. Software checks that the seller does not retain a copy. Once transferred, the item can be bought and downloaded by another customer. ReDigi is set to launch in Europe in a few months.

Digital items on ReDigi are cheaper because they are one-offs. If your hard drive crashes and you lose your iTunes collection you can download it again. But you can only download an item from ReDigi once – there is no other copy. That is the trade-off that makes a second-hand digital market work: the risk justifies the price. The idea has ruffled a few feathers – last year EMI sued ReDigi for infringement of copyright. A judge denied the claim, but the case continues.

Used digital goods can also come with added charm. ReDigi tracks the history of the items traded so when you buy something, you can see who has owned it and when. ReDigi's second-hand marketplace has grown into a social network. According to ReDigi founder John Ossenmacher, customers like seeing who has previously listened to a song. "It's got soul like an old guitar," he says. "We've introduced this whole feeling of connectedness."

It could be good for business too if the original vendors, such as iTunes, were to support resale and take a cut of the resell price. Nevertheless, Amazon's move bucks the industry trend. Microsoft's new Xbox, for example, is expected not to work with second-hand games.

But the market could change rapidly now that Amazon's weight is behind this, says Ossenmacher. "The industry is waking up."

This article appeared in print under the headline "Old MP3, one careful owner"

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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Maldivain ex-leader exits Indian embassy: New Delhi

NEW DELHI: Former Maldives president Mohamed Nasheed left the Indian embassy in the capital Male on Saturday, an Indian official said, 10 days after he sought refuge in the mission in a bid to avoid arrest.

Nasheed's exit came after a Maldivian court earlier this week postponed his trial for abuse of power when he was in office and India sent an envoy to the nation of 330,000 Sunni Muslims to try and end the political standoff.

"He (Nasheed) entered India's mission on February 13th of his own volition and decided to leave on his own," Indian foreign ministry spokesman Syed Akbaruddin said in New Delhi.

Nasheed, 45, is accused of abusing his powers after he won the first free elections in 2008 in the Indian Ocean holiday destination. The pro-democracy campaigner was ousted last year following a mutiny by police and troops.

"He is not planning to go back (to the embassy). He has ended seeking refuge there," Nasheed's Maldivian Democratic Party spokeswoman Shauna Aminath told AFP.

Nasheed, a famed global warming activist, has condemned the charges of abuse of power against him as a "politically motivated sham".

The Maldivian court postponed the hearing scheduled for last Wednesday after police said they were unable to arrest the former president and bring him before the magistrate, according to Nasheed's party.

Presidential spokesman Masood Imad had confirmed the hearing had been cancelled but said that the case was still pending.

Nasheed's taking refuge at the Indian embassy in Male had strained relations between India and its tiny neighbour.

The Maldivian foreign ministry last weekend summoned Indian High Commissioner (ambassador) D.M. Mulay and accused India of allowing Nasheed to use its embassy for political activities.

India had appealed to its neighbour to guarantee "the integrity of the electoral process" before the presidential election set for September, but had strongly denied interfering in politics in the Maldives.

-AFP/fl

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Pentagon grounds entire F-35 Joint Strike Fighter fleet

A crack in an engine blade has suspended airborne testing on the $396 billion Joint Strike Fighter program.

(Credit:
Department of Defense)

The U.S. Department of Defense has suspended airborne testing of its Joint Strike Fighter because of a crack in an engine turbine blade discovered during routine inspection, the Pentagon said this week.

The grounding covers every one of the three versions of the F-35 involved in the $396 billion program -- 51 fighter jets that had hitherto been active for testing and training and have been described by the Pentagon as "the most affordable, lethal, supportable, and survivable aircraft ever to be used."

Just 10 days ago, one of the three versions of the fighter, the F-35B, designed for the Marines, was cleared to resume tests after a monthlong suspension having to do with a fuel line defect.

To understand the specific cause of the current issue -- the cracked turbine blade discovered February 19 -- the engine is being returned to the manufacturer: United Technologies unit Pratt & Whitney. The Pentagon said it hopes to return the fleet to the air as soon as possible.

Eventually, there will be more than 2,400 of the next-generation fighter jets, which will come in three models: the Air Force's agile F-35A, the Marines' VTOL model F-35B, and the Navy's F-35C, which has a larger wing surface and reinforced landing gear to withstand catapult launches and deck landings on an aircraft carrier.

The Pentagon stressed yesterday that the grounding is precautionary and that it's not possible to know the impact of the crack on the low pressure turbine blade until the investigation is complete.

Additional delays aside, the warplane is currently expected to formally take to the skies and be battle-ready in 2018 or 2019.

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Space Pictures This Week: Space Rose, Ghostly Horses

• 
  
  
  
  
  
  
  

  Space Rose

  Image courtesy T.A. Rector and H. Schweiker, UAA/WIYN/NOAO/NSF

  Planetary nebula Sh2-174 "blooms" like a rose in a picture released this week by the National Optical Astronomy Observatory (NOAO).

  Nebulae are created when low-mass stars shed their outer layers at the end of their lives. The core of the dying star, called a white dwarf, usually remains at the center of the nebula.

  But not so for the oddly positioned Sh2-174: Its white dwarf is located in the right part of the nebula, in the blue gas pictured above. (See more nebula pictures.)

  Published February 22, 2013

  
  











• 
  
  
  
  
  
  
  

  Universal Delivery

  Photograph courtesy NASA

  An unpiloted resupply vehicle snapped this picture as it approached the International Space Station this week.

  The vehicle provided the 34 crew members on board with essential supplies, including oxygen, water, spare parts, even logistics equipment—2.9 tons of supplies in all. (See pictures of early U.S. spaceflight.)

  Published February 22, 2013

  
  











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  Everglades of Europe

  Image courtesy Jesse Allen and Robert Simmon, EO-1/NASA/USGS

  The Danube cuts a jade path across part of the Danube Biosphere Reserve in the Ukraine on its way to the Black Sea in an image captured February 5 by NASA's Earth Observing-1 satellite.

  Europe's largest river, the Danube spans 309,447 square miles (801,463 square kilometers) and winds its way through 19 countries.

  Called the "Everglades of Europe," the Danube delta is home to more than 300 species of birds and 45 species of fish, according to NASA's Earth Observatory. (See more river pictures.)

  Published February 22, 2013

  
  











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  Bird's-Eye View

  Image by Maurizio Cabibbo, My Shot

  Photographer Maurizio Cabibbo submitted this picture of the chaotic center of the Cygnus, or Swan, constellation on February 11 to the National Geographic photo community My Shot.

  Resembling a swan flying across the night sky, Cygnus is easily seen in the summer in the Northern Hemisphere, according to NASA.

  Published February 22, 2013

  
  











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• 
  
  
  
  
  
  
  

  Spirit Horses

  Photograph by Andre Erlich, Your Shot

  An aurora casts a ghostly glow over horses in northern Iceland in a picture submitted to National Geographic's My Shot photography community on February 18.

  Named after Aurora, the Roman goddess of dawn, the vivid beams of light from aurora borealis result from collisions between charged particles released from the sun's atmosphere and gaseous particles in Earth's atmosphere. (See more aurora pictures: "Solar Flare Sparks 'Snakes,' 'Spears.'")

  Published February 22, 2013

  
  











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  Image courtesy SDO/NASA

  Published February 22, 2013

  
  

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Great Energy Challenge Blog

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Cyberattacks Bring Attention to Security Reform

Recent accusations of a large-scale cyber crime effort by the Chinese government left many wondering what immediate steps the president and Congress are taking to prevent these attacks from happening again.

On Wednesday, the White House released the administration's Strategy on Mitigating the Theft of U.S. Trade Secrets as a follow-up to the president's executive order. The strategy did not outwardly mention China, but it implied U.S. government awareness of the problem.

"We are taking a whole of government approach to stop the theft of trade secrets by foreign competitors or foreign governments by any means -- cyber or otherwise," U.S. Intellectual Property Enforcement Coordinator Victoria Espinel said in a White House statement.

As of now, the administration's strategy is the first direct step in addressing cybersecurity, but in order for change to happen Congress needs to be involved. So far, the Cyber Intelligence Sharing and Protection Act (CISPA) is the most notable Congressional legislation addressing the problem, despite its past controversy.

Last April, CISPA was introduced by House Intelligence Committee Chairman Mike Rogers, R-Mich., and Rep. Dutch Ruppersberger, D-Md. The act would allow private companies with consumer information to voluntarily share those details with the NSA and the DOD in order to combat cyber attacks.

Peter Parks/AFP/Getty Images

The companies would be protected from any liabilities if the information was somehow mishandled. This portion of the act sounded alarm bells for CISPA's opponents, like the ACLU, which worried that this provision would incentivize companies to share individuals' information with disregard.

CISPA passed in the House of Representatives, despite a veto threat from the White House stemming from similar privacy concerns. The bill then died in the Senate.

This year, CISPA was reintroduced the day after the State of the Union address during which the president declared an executive order targeting similar security concerns from a government standpoint.

In contrast to CISPA, the executive order would be initiated on the end of the government, and federal agencies would share relevant information regarding threats with private industries, rather than asking businesses to supply data details. All information shared by the government would be unclassified.

At the core of both the executive order and CISPA, U.S. businesses and the government would be encouraged to work together to combat cyber threats. However, each option would clearly take a different route to collaboration. The difference seems minimal, but has been the subject of legislative debates between the president and Congress for almost a year, until now.

"My response to the president's executive order is very positive," Ruppersberger told ABC News. "[The president] brought up how important information sharing is [and] by addressing critical infrastructure, he took care of another hurdle that we do not have to deal with."

Addressing privacy roadblocks, CISPA backers said the sharing of private customer information with the government, as long as personal details are stripped, is not unprecedented.

"Think of what we do with HIPAA in the medical professions; [doctors do not need to know] the individual person, just the symptoms to diagnose a disease," Michigan Gov. John Engler testified at a House Intelligence Committee hearing in an attempt to put the problem into context.

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